Mix and Matching of COVID-19 Vaccines
- Using second dose a different vaccine product other than the first dose
- Reasons for mix and matching
- Vaccine shortage for the second dose
- Increasing immunogenicity
- Enhancing vaccine effectiveness
- Contraindication to a specific vaccine after the first dose
- Changes in guidance for vaccine usage
- mRNA vaccines can be used as subsequent doses after initial doses of vectored vaccine and vice versa. AstraZeneca and any of the mRNA vaccines can also be used after initial doses of inactivated vaccines.
Mix and Match*
First Dose | Second Dose |
AstraZeneca | Pfizer |
Pfizer | AstraZeneca |
*Note: - If a person has received AstraZeneca as a first dose and is going to receive Pfizer for the second dose, write down Pfizer in brackets on COV2 and record the batch number on the register.
Contraindications
- A history of anaphylaxis to any type of the vaccine
- People who have an anaphylactic reaction following the first dose of this vaccine